What is Palmitoylethanolamide (PEA)?

PEA is a food supplement based on a natural fatty-acid like compound, found in eggs and milk. This natural substance is a physiologically active molecule that the body produces naturally in small amounts.

PEA is a glial cell modulator. Glial cells are Central Nervous System cells that release many inflammatory substances that act upon neurons, amplifying pain (Watkins and Maier, 2002). With time, PEA modulates (or tones down) pain.

PEA is well tolerated with no significant side effects and drug-to-drug interactions been identified.

Compounded PEA capsules are available without a prescription from Fremantle Central Pharmacy. Nonetheless, we still prefer you to consult with your doctor first before commencing therapy.

If you would like to learn more about PEA, please feel free to get in touch with our friendly pharmacists.

Further reading:

Jan M. Keppel Hesselink (2012). “New Targets in Pain, Non-Neuronal Cells, and the Role of Palmitoylethanolamide”. The Open Pain Journal. 5(1): 12-23 February 2012

Antonio Gatti, MD Marzia Lazzari, MD Valentina Gianfelice, MD Annarita Di Paolo, MD Elisabetta Sabato, MD Alessandro Fabrizio Sabato, MD. “Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis”. Pain Medicine, Volume 13, Issue 9, 1 September 2012, Pages 1121–1130